INFO:

Diphenidine is a lesser-known novel dissociative substance of the diarylethylamine class that produces dissociative and hallucinogenic effects when administered. It is structurally related to methoxphenidine and ephenidine.

The synthesis of diphenidine was first reported in 1924. Shortly after the 2013 UK arylcyclohexylamine ban, diphenidine and the related compound methoxphenidine became available on the grey market. In 2014, there were two cases of diphenidine being sold in combination with synthetic cannabinoids in Japanese herbal incense blends, one of which was implicated in a fatal overdose.

Diphenidine is classified as an NMDA receptor antagonist. Members of this class induce a state known as "dissociative anesthesia" and are used in both medical and recreational contexts. These include arylcyclohexylamines like ketamine and phencyclidine (PCP), as well as dextromethorphan (DXM).

Anecdotal reports describe high doses of diphenidine producing "bizarre somatosensory phenomena and transient anterograde amnesia."

Very little data exists about the pharmacological properties, metabolism, and toxicity of diphenidine in humans, and it has an extremely limited history of human usage. Many reports suggest that it may pose different risks than traditional dissociatives. It is highly advised to use harm reduction practices if using this substance.

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