Diclazepam (also known as Chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepam, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. In animal models it has a potency of approximately ten times that of diazepam, of which it is a structural analog.

Diclazepam is not currently marketed as a medication, but rather sold online as a research chemical. Its potency has not been systematically tested in humans, but its closest relatives and two main metabolites are lormetazepam with a potency value of x10-12 of delorazepam which is roughly x10 the potency of diazepam.

Users should note that the sudden discontinuation of benzodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to taper one's dose by gradually lowering the amount taken each day over a prolonged period of time rather than stopping use abruptly, as this can lead to crippling, potentially life-threatening withdrawal symptoms.

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